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Sildenafil (compound UK-92,480) was synthesized by buy fioricet online a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility. It buy phentermine online was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascular disease). Phase I clinical trials under the buy cialis online direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections.[1][2] Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction buy didrex online by the Food and Drug Adminis
tration on March 27, buy online tramadol 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year.[3] It soon became a great success:buy adipex online annual sales of Viagra in buy alprazolam online the period 1999–2001 exceeded $1 billion.
The British press buy xenical online portrayed Peter Dunn and Albert Wood as the inventors of the drug, a buy ambien online claim which Pfizer disputes.[4] Their buy tenuate online names are on the manufacturing patent application drug, but buy valium online Pfizer claims this is only for convenience.
Even though sildenafil is buy allegra online only available by prescription from a doctor, it was advertised directly to consumers on US TV (famously being endorsed by former United States Senator Bob Dole and football star Pele). Numerous sites on the Internet offer Viagra for sale after an "online consultation", a mere web questionnaire. The "Viagra" name has become so well known that many fake aphrodisiacs now call themselves "herbal Viagra" or are presented as blue tablets imitating the shape and colour of Pfizer's product. Viagra is also informally known as "Vitamin V", "the Blue Pill", as well as various other nicknames.
In February 2007, it buy levitra online was announced that Boots the Chemist would trial over the counter sales of Viagra in stores buy vicodin online in Manchester, England. Men aged between 30 and 65 would be eligible buy ultram online to buy four tablets after a consultation with a pharmacist.[5]
Pfizer's buy adderall online worldwide patents on sildenafil citrate will expire buy carisoprodol online in 2011–2013. The UK patent held by buy online soma Pfizer on the use of PDE5 inhibitors (see below) as buy lipitor online treatment of impotence was invalidated in 2000 because of obviousness; this decision was buy propecia online upheld on appeal in 2002.
Part of the physiological process of erection involves the parasympathetic nervous system causing the release of nitric oxide (NO) in the corpus cavernosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) in the corpus cavernosum, resulting in increased inflow of blood and an erection.
Sildenafil is a potent and buy diazepam online selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for buy viagra online degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis®) and vardenafil (Levitra®).
Sildenafil is metabolised by buy xanax online hepatic enzymes and excreted by both the liver and kidneys. If taken with a high-fat meal, there may be a delay in absorption of sildenafil and the peak effect might be reduced slightly as the plasma buy hydrocodone online concentration will be lowered.
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